Today’s presentation by Dr. Alessandro Scavuzzo from Brescia University Hospital at the European Congress of Radiology further demonstrates the utility of TexRAD on MRI in a new application in cardiovascular disorders (e.g. dilated cardiomyopathy) specifically highlighting the ability of TexRAD MR texture analysis as a non-invasive imaging biomarker showing association with the clinical score and patient outcome
Provided by University of Brescia.
Presentation Title: Role of late gadolinium enhancement, myocardium native T1 value and texture analysis in patients affected by dilated cardiomyopathy: clinical score and outcome correlation.
Purpose: To correlate late gadolinium enhancement (LGE) myocardium T1 value, texture analysis and the outcome in patients affected by dilated cardiomyopathy (DMC).
Methods and Materials: Retrospective evaluation on 104 DMC affected patients who underwent cardiac MR (CMR) between January 2012 and May 2015. Exam protocol included morphologic sequences, cine MR, native T1 mapping and after gadolinium PSIR sequences. LGE was analysed drawing ROIs on short-axis PSIR, T1 delineating the cardiac septum on native short-axis ShMOLLI and texture analysis delineating the septum on short-axis cine MR using TexRAD software. Outcome was set as major cardiac events (MACE) 6 months within the exam
Results: 53/104 patients presented LGE and they showed a higher percentage of MACE compared to patients without LGE (37% vs. 7% respectively, p=0.001). The extension of LGE did not correlate with MACE, the ejection fraction or the end diastolic volumes (t test, p=ns). T1 was measured on 34 patients, 21 with LGE (mean 1033msec) and 13 without LGE.
(mean 1008msec)(p=ns). Significant difference was shown between T1 of patients with MACE (11/34, mean 1045msec) and without MACE (23/24, mean 1011msec)(p=0.02). Texture analysis showed correlation between patients with and without MACE, with kurtosis at 1mm filter being the most significant value (t test, p=0.0019).
Conclusion: Both the presence of LGE and native T1 value of myocardium correlate with MACE. Correlation between T1 and LGE has not been proved. Texture analysis has demonstrated a potential on defining diffuse myocardium fibrosis (particularly with thin filters) and is easily applicable, but is still not supported by enough literature data.