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DirectorsTalk – Q&A with Professor Steve Myers at Advanced Oncotherapy (AVO).

Advanced Oncotherapy PLC (LON:AVO) subsidiary ADAM S.A. Executive Chairman professor Steve Myers talks to DirectorsTalk about the LIGHT system, it’s likely impact, the design, the progress being made and its future.
Q1: Professor Myers, you became Executive Chairman of ADAM S.A. (ADAM), the CERN spin-off and Advanced Oncotherapy’s (AVO’s) subsidiary, in late 2015, and joined AVO’s Board earlier this year. Your primary responsibility is overseeing the development of AVO’s proprietary and novel proton beam therapy (PBT) technology, LIGHT?

A1: Yes, that’s right. The single most important aspect of LIGHT is that it is based on a fundamentally different design to all other PBT systems. All existing technologies are based on cyclotrons or synchrotrons; LIGHT is the only linear proton accelerator designed for medical application in the treatment of cancer.

Q2: Does that matter?

A2: It matters a great deal. These differences, in terms of technology and costs, have major implications for LIGHT’s potential disruption of the global radiotherapy market. Its technology provides a paradigm shift in clinical effectiveness: the speed at which the energy and direction of the beam can be modulated, the production of secondary radiation, shielding requirements, beam size, size of magnets along the beam transfer line and, hence, the size of the patient gantry, these are all radically better with a linear accelerator.

Costs, in regards to upfront capital expenditure, ongoing maintenance and decommissioning, have also proven prohibitively high for hospitals and clinics when considering existing technologies. LIGHT will be available at a fraction of the cost of comparable competing systems.

Q3: So why aren’t there more linear proton accelerators in hospitals?

A3: From a design perspective, it’s because the engineering behind LIGHT is sufficiently challenging that it has taken the expertise within ADAM, and the experience of continually designing, creating and operating next-generation particle accelerators, to build one.

Q4: How has that expertise translated into LIGHT’s design; can you highlight some examples?

A4: There are a lot, but to pick just one of LIGHT’s components as an example, in February ‘17 we reached a major technical milestone by hitting the desired output energy from the RFQ (Radio Frequency Quadrupole). The RFQ has a number of unique properties: operating at 750 MHz, so it is far smaller than comparable systems, and the energy of the proton beam can be altered 200 times every second, for more accurate tumour targeting and adaptive treatment.

Q5: So where are we with LIGHT?

A5: We outlined the milestones we’re working towards at the investor evenings in March 2017 and hitting those is very much our focus. We updated the market with the progress we have made on the patient positioning system, ionisation chamber and RFQ on June 12th 2017; we’ll be providing further updates on milestones in due course.

Q6: So a major technical event will be generating a proton beam of sufficient energy to treat superficial tumours later in 2018?

A6: That’s right.

Q7: And then, once the first machine has been produced?

A7: There is a huge, unmet medical need for new PBT systems and AVO has been putting the foundations in place to cope with this demand. At the same time, we will keep innovating and continue leveraging LIGHT’s unique capabilities. A potential future addition to LIGHT could be the ability to generate a beam of heavier ions, with higher relative biological effectiveness than even protons. Other enhancements could include enhanced accelerating power and, therefore, a shorter LIGHT system or more efficient radiofrequency generators to reduce already low operating costs. LIGHT’s modular nature lends itself perfectly to the possibility of upgrades and to further improved clinical benefits and/or lower costs.

But, I should stress that the Advanced Oncotherapy PLC LIGHT is already sufficiently different to existing technology to be hugely disruptive in the current market. Getting LIGHT into mass production is what we’ll be concentrating on.

Professor Steve Myers, Executive Chairman at ADAM S.A. thank you for Joining DirectorsTalk today.

 

Link here to Directors Talk

Advanced Oncotherapy (AVO) – Non-exec Professor Steve Myers buys 400,000 shares at 26p.

Advanced Oncotherapy (AVO), the developer of next-generation proton therapy systems for cancer treatment, announces that Professor Steve Myers, Non-Executive Director of the Company, has purchased today a total of 400,000 ordinary shares of 25 pence in the Company at a price of 26 pence per Ordinary Share.

Following this transaction, Professor Myers holds 450,569 Ordinary Shares, representing 0.59% of the Company’s issued capital. 

Advanced Oncotherapy Plc

www.avoplc.com

Dr. Michael Sinclair, Executive Chairman

Tel: +44 20 3617 8728

Nicolas Serandour, CEO

Stockdale Securities (Nomad & Joint Broker)

Antonio Bossi / David Coaten

Tel: +44 20 7601 6100

Stifel Nicolaus Europe (Joint Broker)

Jonathan Senior / Ben Maddison

Tel: +44 20 7710 7600

Walbrook PR (Financial PR & IR)

Tel: +44 20 7933 8780 or avo@walbrookpr.com

Paul McManus / Anna Dunphy

Mob: +44 7980 541 893 / Mob: +44 7876 741 001

Advanced Oncotherapy (AVO) – Appointment of Non-Executive Directors

 

Advanced Oncotherapy (AVO), the developer of next-generation proton therapy systems for cancer treatment, announces the appointment of Professor Steve Myers OBE and Mr Hans von Celsing as Non-Executive Directors with immediate effect. In addition, Mr von Celsing will become Senior Independent Non-Executive Director. Professor Myers’ appointment follows the announcement of the Company’s intention to do so, on 1 November 2016.

At the same time, Tim Lebus, Non-Executive Director, will stand down with immediate effect.

Professor Steve Myers

Professor Myers has been part of the Advanced Oncotherapy Leadership Team since his appointment as Executive Chairman of the Company’s fully owned subsidiary ADAM S.A., in November 2015. Before joining Advanced Oncotherapy, Professor Myers was Head of Medical Applications at CERN in Geneva and before that, was Director of Accelerators and Technology at CERN. There, he was responsible for the operation and exploitation of the whole accelerator complex, with particular emphasis on the Large Hadron Collider (“LHC”) and the development of new projects and technologies.

He is a Fellow of the Royal Academy of Engineering, the Institute of Physics, the European Physical Society and International Fellow of the American Physical Society. He is internationally recognised for his engineering contributions and leadership in the development of CERN’s particle colliders over the past 40 years, including the Intersecting Storage Ring Accelerator, the Large Electron-Positron collider and the LHC.

Professor Myers has been awarded a number of international prizes including the EPS Edison Volta Prize and the Prince of Asturias Prize of Spain. He was awarded an OBE in 2013 for services to science and technology. Professor Myers holds a number of honorary degrees and advisory positions and is Chair of the Advisory Committees of both the John Adams Accelerator Institute in Oxford and the Cockcroft Accelerator Institute. He has published over 300 scientific papers.

Mr Hans von Celsing

Mr von Celsing was an Adviser to Mevion Medical Systems for eight years and supported their international expansion in Europe and Asia. Mr von Celsing also joined Elekta, as Executive Vice President, in its early stages in 1985. Elekta, a publicly quoted, Swedish medical technology group, is the leading supplier of equipment instrumentation and information systems for use in neuroscience, cancer care and oncology management. Both Elekta and Mevion are active in the Radiation Oncology Technology market.

Mr von Celsing has held a number of Board level roles throughout his career, and has particular expertise in the areas of life sciences, medical devices and diagnostics. Mr von Celsing is currently Chairman of Clinical Laser Thermia Systems, a public quoted medical technology company in Lund, Sweden. He is also Chairman of Gelexir Healthcare Ltd, a medical technology company based in Manchester, Chairman of Partner Fondkommission, an independent investment banking company based in Gothenburg, Sweden, and Chairman of Peptonic Medical, a publicly quoted biopharmaceutical company in Stockholm.

Mr von Celsing’s considerable experience in the growth of radiation therapy companies and in corporate governance makes him ideally placed to join Advanced Oncotherapy as Senior Independent Non-Executive Director.

Commenting, Michael Sinclair, Executive Chairman of Advanced Oncotherapy said: “Steve and Hans are hugely experienced in their respective fields. Steve’s background at CERN and his work with accelerator technology and the medical application of this technology have been invaluable to the business since he joined us in 2015. Hans has a wealth of knowledge in the sector and his CV speaks for itself in terms of his experience at Board level. We are looking forward to having him join us and the value he will no doubt add to the team.

“Finally, I would like to thank Tim Lebus for his immense contribution to the Board over the last three and a half years. Tim’s experience in private equity and banking has been incredibly helpful as the company has progressed and we are very grateful for his guidance and we wish him well for the future.” 

Commenting, Hans von Celsing, said: “I am honoured to be asked to join the Advanced Oncotherapy Board as Senior Independent Non-Executive Director. The Company’s technology is truly amazing and promises to shape the next generation of radiation therapy equipment. What really impresses me is the quality of the team, the deep technical knowledge they have and the Company’s collaboration with CERN, the preeminent particle physics institute.  The foundation is there for a great commercial success story in the medical technology field.” 

Information to be disclosed under Schedule 2(g) and Rule 17 of the AIM rules

Professor Steve Myers (aged 70), currently owns 50,569 shares in Advanced Oncotherapy

Current Directorships Directorships in the last five years
ADAM S.A. European Organisation for Nuclear Research (CERN)

Mr Hans Henrik von Celsing (aged 66)

Current Directorships Directorships in the last five years
Clinical Laser Thermia Systems AB Sonowand A/S
Gelexir Healthcare Ltd BiOxyDyn Ltd
Partner Fondkommission
Peptonic Medical Ltd

Mr von Celsing holds no ordinary shares of the Company and holds share options over 200,000 ordinary shares at an exercise price of 250p.

Other than the information contained in this announcement, there is no further information required to be disclosed under Rule 17 and Schedule Two, paragraph (g) of the AIM Rules.

For further information, please contact:

Advanced Oncotherapy plc www.avoplc.com
Nicolas Serandour, Chief Executive Officer Tel: +44 20 3617 8728
Michael Sinclair, Executive Chairman
Stockdale Securities (Nomad & Joint Broker) Tel: +44 20 7601 6100
Antonio Bossi / David Coaten
Stifel Nicolaus Europe (Joint Broker) Tel: +44 20 7710 7600
Jonathan Senior / Ben Maddison
Walbrook PR (Financial PR & IR) Tel: +44 20 7933 8780 or avo@walbrookpr.com
Paul McManus Mob: +44 7980 541 893
Anna Dunphy Mob: +44 7876 741 001

About Advanced Oncotherapy plc www.avoplc.com 

Advanced Oncotherapy is a provider of particle therapy with protons that harnesses the best in modern technology. Advanced Oncotherapy’s team “ADAM”, based in Geneva, focuses on the development of a proprietary proton accelerator called Linac Image Guided Hadron Technology (LIGHT). LIGHT accelerates protons to the energy levels achieved in legacy machines but in a unit that is a quarter of the size and between a quarter and a fifth of the cost. This compact configuration delivers proton beams in a way that facilitates greater precision and electronic control which is not achievable with older technologies. 

Advanced Oncotherapy will offer healthcare providers affordable systems that will enable them to treat cancer with an innovative technology as well as better health outcomes and lower treatment related side effects. 

Advanced Oncotherapy continually monitors the market for any emerging improvements in delivering proton therapy and actively seeks working relationships with providers of these innovative technologies. Through these relationships, the Company will remain the prime provider of an innovative and cost-effective system for particle therapy with protons.

 

Advanced Oncotherapy (AVO) – Further progress in the technical development of the LIGHT system

AVO1Advanced Oncotherapy (AIM: AVO), the developer of next-generation proton therapy systems for cancer treatment, announces that the Company has integrated the proton source and Radio Frequency Quadruple (RFQ), following a successful testing and calibration programme at ADAM, in Geneva.

This work has demonstrated there is a predicted acceleration of the proton beam through this very sophisticated structure, the RFQ, and that the measurements matched those expected from computer simulations. The completion of this key milestone is a significant indicator of the continued successful technical development of the Company’s LIGHT proton system.

Advanced Oncotherapy’s Professor Steve Myers, Executive Chairman of ADAM and previously Director of Accelerators and Technology at CERN and Head of CERN Medical Applications, stressed the significance of designing and building an RFQ with notably higher frequency and, hence, shorter wavelength and smaller dimensions than current comparable linear accelerators.

In the video recently made available on the Company’s website, Paul Collier, Head of Beams Department at CERN, spoke about the unique features of AVO’s LIGHT system’s RFQ, which has been designed and built by CERN:

“This high frequency RFQ is the most beautiful piece of equipment I have been involved in manufacturing. This is a very important piece of technology transfer from CERN to the outside world. We were challenged to design and build the world’s highest frequency and highest power RFQ.”

Advanced Oncotherapy Plc

www.avoplc.com

Dr. Michael Sinclair, Executive Chairman

Tel: +44 20 3617 8728

Nicolas Serandour, CEO

Stockdale Securities (Nomad & Joint Broker)

Antonio Bossi / David Coaten

Tel: +44 20 7601 6100

Stifel Nicolaus Europe (Joint Broker)

Jonathan Senior / Ben Maddison

Tel: +44 20 7710 7600

Walbrook PR (Financial PR & IR)

Tel: +44 20 7933 8780 or avo@walbrookpr.com

Paul McManus / Anna Dunphy

Mob: +44 7980 541 893 / Mob: +44 7876 741 001

About Advanced Oncotherapy Plc www.avoplc.com

Advanced Oncotherapy is a provider of particle therapy with protons that harnesses the best in modern technology. Advanced Oncotherapy’s team “ADAM”, based in Geneva, focuses on the development of a proprietary proton accelerator called Linac Image Guided Hadron Technology (LIGHT). LIGHT accelerates protons to the energy levels achieved in legacy machines but in a unit that is a quarter of the size and between a quarter and a fifth of the cost. This compact configuration delivers proton beams in a way that facilitates greater precision and electronic control which is not achievable with older technologies.

Advanced Oncotherapy will offer healthcare providers affordable systems that will enable them to treat cancer with an innovative technology as well as better health outcomes and lower treatment related side effects.

Advanced Oncotherapy continually monitors the market for any emerging improvements in delivering proton therapy and actively seeks working relationships with providers of these innovative technologies. Through these relationships, the Company will remain the prime provider of an innovative and cost-effective system for particle therapy with protons.

Advanced Oncotherapy (AVO) – Directorate Change

AVO1Advanced Oncotherapy (AIM: AVO), the developer of next-generation proton therapy systems for cancer treatment, announces that Lord David Evans has stepped down from the Board with immediate effect. In addition, the board of directors of Advanced Oncotherapy intends to appoint Professor Stephen Myers as member of the Board. A further announcement in relation to the proposed appointment of ProfessorStephen Myers will be made in due course.

Professor Steve Myers OBE, was appointed Executive Chairman of Advanced Oncotherapy’s fully owned subsidiary ADAM S.A. a year ago and, since then, has delivered with the ADAM team significant progress in designing and developing the Company’s next-generation proton beam cancer therapy technology, the ground-breaking LIGHT system.

Professor Myers was Head of Medical Applications at CERN in Geneva from 2014 until 2016. From 2009-2013, he was the Director of Accelerators and Technology, where he was responsible for the operation and exploitation of the whole CERN accelerator complex, with particular emphasis on the Large Hadron Collider and for the development of the new projects and technologies.

In 2012, he was elected as a Fellow of the Royal Academy of Engineering which honours the UK’s most eminent engineers, and is a Fellow of the Institute of Physics, the European Physical Society and International Fellow of the American Physical Society. He is internationally recognised for his engineering contributions and leadership in the development of CERN’s particle colliders over the past 40 years, including the Intersecting Storage Ring Accelerator, the Large Electron-Positron collider and the LHC. 

Professor Myers has been awarded a number of international prizes including the Duddel Prize & Medal from the Institute of Physics (now re-named the Gabor Medal & Prize) and was awarded an OBE in 2013 for services to science and technology. Professor Myers holds a number of honorary and advisory positions and is Chair of the Advisory Committees of both the John Adams Accelerator Institute in Oxford and the Cockcroft Accelerator Institute and has published over 300 scientific papers.

Commenting, Mike Sinclair, Executive Chairman of Advanced Oncotherapy, said: “We are very pleased with the proposed appointment of Professor Steve Myers to the Board. Since his appointment at ADAM, Professor Steve Myers has provided the Company with invaluable advice and extensive knowledge. We are extremely lucky to have someone of his calibre joining the board of Advanced Oncotherapy. On behalf of the Board, I would like to thank Lord Evans for his hard work and dedication over the years, and wish him every success in the future. David has been involved with the Company since its inception and has made a significant contribution to our development in terms of both his commercial and political prowess, and for which we are very grateful.”

Commenting, Prof. Stephen Myers, said: “I am very pleased to be part of Advanced Oncotherapy, both asExecutive Chairman of ADAM and in the future as member of the Board of Advanced Oncotherapy. This represents a unique opportunity and I look forward to sharing further my own experience and knowledge of the industry with the company. 

Advanced Oncotherapy Plc

www.avoplc.com

Dr Michael Sinclair, Executive Chairman

Nicolas Serandour, CEO

Tel: +44 20 3617 8728

  

   Stockdale Securities (Nomad & Joint Broker)

Antonio Bossi / David Coaten

Tel: +44 20 7601 6100

   Beaufort Securities (Joint Broker)

Jon Belliss / Elliot Hance

Tel: +44 20 7382 8300

   Walbrook PR (Financial PR & IR)

Paul McManus / Anna Dunphy

Tel: +44 20 7933 8780 or avo@walbrookpr.com

Mob: +44 7980 541 893 / Mob: +44 7876 741 001

About Advanced Oncotherapy Plc www.avoplc.com

Advanced Oncotherapy is a provider of particle therapy with protons that harnesses the best in modern technology. Advanced Oncotherapy’s team “ADAM”, based in Geneva, focuses on the development of a proprietary proton accelerator called Linac Image Guided Hadron Technology (LIGHT). LIGHT accelerates protons to the energy levels achieved in legacy machines but in a unit that is a quarter of the size and between a quarter and a fifth of the cost. This compact configuration delivers proton beams in a way that facilitates a greater precision and electronic control which is not achievable with older technologies. 

Advanced Oncotherapy will offer healthcare providers affordable systems that will enable them to treat cancer with an innovative technology as well as better health outcomes and lower treatment related side effects.

Advanced Oncotherapy continually monitors the market for any emerging improvements in delivering proton therapy and actively seeks working relationships with providers of these innovative technologies. Through these relationships, the Company will remain the prime provider of an innovative and cost-effective system for particle therapy with protons.

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