Open Orphan is a rapidly growing specialist CRO pharmaceutical services company which has a focus on orphan drugs and is a world leader in the provision of virology and vaccine challenge study services and viral laboratory services. It has Europe’s only 24-bedroom quarantine clinic with onsite virology lab in Queen Mary’s Hospital London. Here, wholly owned subsidiary hVivo supports product development for customers developing antivirals, vaccines and respiratory therapeutics, all particularly relevant and topical in the environment of heightened awareness of the Corona virus in 2020.
Open Orphan comprises of two commercial specialist CRO services businesses (Venn and hVIVO) and is developing an early stage orphan drug genomics data platform business capturing valuable genetic data from patient populations with specific diseases with designated orphan drug status and incorporating AI tools.
In June 2019, Open Orphan acquired AIM-listed Venn Life Sciences Holdings plc in a reverse take-over and in January 2020 it completed the Merger with hVIVO plc. Venn, as an integrated drug development consultancy, offers CMC (chemistry, manufacturing and controls) , preclinical, phase I & II clinical trials design and execution.
The Merger with hVIVO created a European full pharma services company broadening the Company’s customer base and with complementary specialist CRO services, widened the range of the Company’s service offering.

Follow Open Orphan on Twitter @OpenOrphan
- Alan Green talks oil, commodities, plus Mosman Oil & Gas #MSMN, Open Orphan #ORPH & Watches of Switzerland #WOSG on UK Investor Magazine podcast
- Open Orphan #ORPH – Ethics approval – COVID-19 Human Challenge Study
- Open Orphan #ORPH – Exercise of Investor Warrants by Investors, Issue of Shares and TVR
- Open Orphan #ORPH – New challenge study quarantine clinic at Whitechapel
- Open Orphan #ORPH – Contract extension with Carna Biosciences
- Bidstats confirmation of hVIVO contract award as announced by Open Orphan #ORPH in October 2020
- Open Orphan #ORPH – Article Published in Drug Discovery Today
- Open Orphan #ORPH – Expansion of volunteer recruitment centres for human challenge trials
- Alan Green discusses ESG and renewables, plus British Honey Co #BHC, Open Orphan #ORPH & Itaconix #ITX on UK Investor Magazine podcast
- Open Orphan #ORPH – First volunteer dosed in intranasal COVID-19 vaccine clinical trial
- Open Orphan #ORPH – Contract renewal with top-3 global pharmaceutical client
- Alan Green talks Open Orphan #ORPH, Blue Prism #PRSM & Power Metal Resources #POW on Vox Markets podcast
- Daily Mail – The volunteers who are DELIBERATELY catching Covid: 2,500 Britons will take part in the world’s first ‘human challenge trials’ run by Imperial College next month in bid to accelerate research on pandemic
- Open Orphan #ORPH – Successful completion of PrEP Biopharm Toxicology study for respiratory ‘viral mimic’
- Open Orphan #ORPH – Successful extension of contract with top-3 global pharmaceutical client underpins 2021 revenue growth expectations
- Open Orphan #ORPH Chairman Cathal Friel talks to Ian King, Sky News about the Codagenix nasal Covid-19 vaccine phase I study
- Vaccine spray goes for testing – The Times, Tom Howard
- BRR Media – Open Orphan #ORPH secure MHRA approval to start Codagenix COVID-19 phase 1 vaccine trial
- Open Orphan #ORPH – MHRA approval for nasal COVID-19 vaccine clinical trial
- Pharma Tech Article – Open Orphan #ORPH – Accelerated Vaccine Development with Human Challenge Studies
- Open Orphan #ORPH subsidiary Venn Life Sciences wins two new contracts
- The Sun – COVID-19: UK scientists to infect volunteers with coronavirus in world first vaccine trial
- Open Orphan #ORPH – Directors Change
- Alan Green presents the investment case for Synairgen #SNG, Omega Diagnostics #ODX, Open Orphan #ORPH & Venture Life #VLG on his weekly Stockbox Media Research talk
- Open Orphan #ORPH – Collaboration Agreement with HIC-VAC and Wellcome Trust
- Open Orphan #ORPH Announces New £2.5m Influenza Challenge Study Contract Win
- Daily Mail – Stock Watch Open Orphan #ORPH October 30th
- Open Orphan #ORPH – New 2-year contract with a tier 1 German pharmaceutical company
- Open Orphan #ORPH / hVIVO Signs Contract with UK Government for the Development of a COVID-19 Human Challenge Study Model
- Alan Green presents the investment case for Open Orphan #ORPH and British Honey Company #BHC on his weekly Stockbox Media Research talk
- Open Orphan #ORPH – Statement re further media comment on UK Government and other partners for a UK Coronavirus challenge study
- Most people try to avoid Covid-19. But thousands are signing up to be deliberately exposed – CNN
- Daily Telegraph – When will a Covid-19 vaccine be ready in the UK? Latest updates from around the world
- Alan Green on Trump/Biden, plus Open Orphan #ORPH, Erris Resources #ERIS & Tertiary Minerals #TYM on the UK Investor Mag podcast
- Open Orphan #ORPH – Interim Results for 6 months ended 30 June, will be operationally profitable in Q4
- The Times – Trial to infect British volunteers with modified coronavirus at hVIVO Quarantine Centre
- Alan Green discusses Open Orphan #ORPH, Kingfisher #KGF & Castillo Copper #CCZ on Vox Markets podcast
- Open Orphan #ORPH – New £4.3m Challenge Study Contract Win with Global Top 10 Vaccine Company
- Open Orphan #ORPH – Statement re price movement and press speculation
- Open Orphan #ORPH – Exercise of Investor Warrants by Investor, Issue of Shares and Total Voting Rights
- Open Orphan #ORPH – Venn Life Sciences New Contract Win
- Open Orphan #ORPH – hVIVO to present at 2020 ERS International Congress
- Vox Markets podcast – Open Orphan #ORPH, Blencowe Resources #BRES & Alan Green on #ESL, #BP & #UJO
- Open Orphan #ORPH – Major New Contract Win with Top 3 Pharma Company
- Open Orphan #ORPH – New Contract Win with Carna Bioscience
- Alan Green talks Smart Metering Systems #SMS, Open Orphan #ORPH & Blencowe Resources #BRES on Vox Markets podcast
- Open Orphan #ORPH Awarded Contract From Codagenix Inc For COVID-19 Vaccine Trial
- Alan Green presents the investment case for Katoro Gold #KAT & Open Orphan #ORPH on his weekly StockBox Research Talk
- Alan Green talks Moderna $MRNA, Open Orphan #ORPH, Tertiary Minerals #TYM & Versarien #VRS on UK Investor Mag podcast
- Open Orphan #ORPH – Option to Acquire CHIMagents Limited
- Alan Green talks Open Orphan #ORPH, Avacta #AVCT & Zanaga #ZIOC, plus ECR Minerals #ECR, Novacyt #NCYT & Gfinity #GFIN on Vox Markets podcast
- Open Orphan #ORPH – Upcoming Investor Events
- Open Orphan #ORPH – Additional Laboratory Services Contracts Signed with NOBACZ & Nearmedic International
- Open Orphan #ORPH – Notice of AGM
- Open Orphan #ORPH – Full Year Results
- Open Orphan #ORPH – Positive Phase 1 study results published in The Lancet
- Experts seek approval for COVID-19 trials – China Daily
- Open Orphan #ORPH – Major New Contract Win for Venn Life Sciences
- Alan Green talks markets, Open Orphan #ORPH, Versarien #VRS & San Leon Energy #SLE on UK Investor Magazine podcast
- Open Orphan plc #ORPH – Launch of Covid-19 Antibody Testing
- Open Orphan #ORPH – Results of Fundraising
- Open Orphan #ORPH – Proposed Fundraising to raise up to £12 million and PrimaryBid.com Offer
- Open Orphan #ORPH – Update on antibody test agreement and recent share price movement
- Alan Green talks funds, Catenae #CTEA, Blencowe Resources #BRES & Open Orphan #ORPH on Vox Markets podcast
- Open Orphan #ORPH – Quotient Limited & hVIVO Partnership to Support Wide-Spread COVID-19 Antibody Testing in the UK
- Open Orphan Chairman Cathal Friel speaks to BRR Media re the new contract, other developments and the CEO’s departure
- Open Orphan #ORPH & Cadence Minerals #KDNC on the Vox Markets podcast
- Open Orphan #ORPH Exec Chairman Cathal Friel speaks to Proactive’s Andrew Scott about the new US biotech deal
- Open Orphan #ORPH – Major New Contract Signed With US Biotech Company for RSV Human Study & CEO Trevor Phillips to Step Down.
- Open Orphan #ORPH: The Times – Inside Story of coronavirus battlers. The Sun – We salute the unsung key workers.
- Irish Independent – Open Orphan subsidiary starts testing drug for treating Covid-19
- Alan Green & Zak Mir discuss Open Orphan #ORPH, Tiziana Life #TILS & Bidstack #BIDS on ShareTalk TV
- Irish Times – Open Orphan to test Covid-19 drug through London subsidiary
- Open Orphan #ORPH – Testing of anti-viral for treating COVID-19 underway
- Open Orphan: Flu vaccine data showcased in peer reviewed article – Proactive Investors
- A view from the hVivo / Open Orphan #ORPH Laboratory – Professor John Oxford
- Alan Green talks market stimulus, oil stocks incl #RDSB & #I3E, plus the Coronavirus battle & #ORPH on UK Investor Magazine podcast
- Race to stop the world getting sick: As coronavirus ravages the globe, experts work around the clock developing vaccines and trialling drugs in a desperate attempt to contain it
- Wanted: People Willing to Get Sick to Find Coronavirus Vaccine
- Alan Green talks market crash, Tiziana Life #TILS, Destiny Pharma #DEST, Open Orphan #ORPH & Cadence Minerals #KDNC on Vox Markets podcast
- Sunday Telegraph – Vaccine hunters: meet the scientists racing to find a cure
- Open Orphan #ORPH – Publication of positive FLU-v vaccine challenge study results in journal
- Alan Green & Sarah Lowther discuss the market crash, lessons from China, plus an array of stocks including Tiziana Life #TILS & Open Orphan #ORPH on the Total Market Solutions podcast
- Daily Mirror – Coronavirus: Inside UK clinic where volunteers get paid up to £4,000 to be infected in race to find vaccine
- BRR Media – Cathal Friel & hVIVO Chief Scientist Andrew Catchpole discuss the Coronavirus Challenge Study and the FLU-V Vaccine
- Proactive Investors – Open Orphan #ORPH catching global attention with ‘stunning’ FLU-v results & world-first coronavirus study
- Open Orphan #ORPH – Publication of Positive Results in Journal
- Open Orphan #ORPH – Completion of the compulsory acquisition of remaining hVIVO shares
- Alan Green talks market crash, scaling in, Shell #RDSB, Open Orphan #ORPH & Eddie Stobart #ESL on Vox Markets podcast
- Open Orphan #ORPH – Development of the World’s First Human Coronavirus Challenge Study Model
- Sunday Times – Coronavirus vaccine race: volunteers to be infected in the UK
- Open Orphan tip of the year update on mega contract win
- Irish Times – Open Orphan seals deal that could net more than €11.6m
- Open Orphan #ORPH – New hVIVO contract signed with a European Biotech Company to provide RSV human challenge study
- Open Orphan #ORPH – Change in Registered Office
- Alan Green talks Coronavirus and markets, plus Open Orphan #ORPH & Metro Bank #MTRO on the UK Investor Magazine podcast
- Shares Magazine Spotlight – Open Orphan lining up for coronavirus fight
- Open Orphan #ORPH – Appointment of new Director
- Open Orphan #ORPH – Result of Rule 15 Offer and Total Voting Rights
- Built to sell – can dealmaker Cathal Friel build (and sell) a £80m company in two years?
- Open Orphan #ORPH presents at ShareSoc Growth Company Seminar, Manchester
- Open Orphan (ORPH) Appoints Professor Oxford as Chair of Advisory Board, with initial focus to help guide Open Orphan in the provision of solutions to Coronavirus outbreak
- Open Orphan #ORPH – Appointment of Group Chief Financial Officer
- Vox Markets Q&A with Open Orphan #ORPH Exec Chairman Cathal Friel
- Open Orphan #ORPH – Value the Markets Webinar
- LSE interview – Cathal Friel refocuses Open Orphan #ORPH as he raises 5m and buys virology specialist hVIVO
- Open Orphan #ORPH presents at Shares Growth and Invention Forum, London
- BRR Media – Open Orphan #ORPH introduces Professor John Oxford
- Open Orphan #ORPH – Upcoming Investor Events
- Proactive Investors interview with the Open Orphan #ORPH team on its future and ‘the lottery ticket’ sitting within hVIVO
- BRR Media – Open Orphan #ORPH business update
- Keeping pace with Open Orphan
- Sunday Times – Irish firm Open Orphan #ORPH lined up for role in coronavirus fight
- Open Orphan #ORPH – Results of Placing and Subscription
- Open Orphan #ORPH – Proposed Placing to raise a minimum of £5 million to fund growth and convert hVIVO proposal pipeline
- Open Orphan #ORPH – Compulsory Acquisition of Remaining hVIVO Shares
- Open Orphan #ORPH – Update on Placing
- Cathal Friel talks to Zak Mir about ‘sleeping giant’ hVIVO, and his plans for the new enlarged Open Orphan #ORPH
- Alan Green talks Open Orphan #ORPH, ECR Minerals #ECR, Destiny Pharma #DEST, Mirriad #MIRI & RA Intl #RAI on Vox Markets podcast
- Open Orphan #ORPH announces completion of the merger with hVIVO and re-admission
- Cathal Friel, Open Orphan #ORPH CEO confirms to Proactive Investors that the hVIVO deal is done
- Open Orphan #ORPH – hVIVO merger offer now wholly unconditional
- Open Orphan #ORPH – Second Closing of the hVIVO Offer, No extension of the Offer
- Alan Green discusses Mirriad #MIRI, i3 Energy #I3E, Polarean Imaging #POLX and Fair Oaks Income #FAIR on Vox Markets podcast
- Open Orphan #ORPH CEO Cathal Friel discusses contract wins & hVIVO #HVO merger on the Vox Markets podcast
- BRR Media interviews Cathal Friel, CEO of Open Orphan #ORPH
- Irish Independent – Open Orphan signs ‘significant’ revenue generating contract
- Open Orphan #ORPH – Result of General Meeting
- Alan Green discusses Open Orphan #ORPH, Mirriad Advertising #MIRI and IXICO #IXI on Vox Markets podcast
- Open Orphan #ORPH – Pre-Admission Announcement for Euronext Growth Markets
- Open Orphan #ORPH – New 3 Year Contract with major Pharmaceutical Company
- Open Orphan #ORPH – hVIVO #HVO offer now unconditional as to acceptances
- Open Orphan #ORPH – New Contract with SFA Therapeutics
- Alan Green talks Cadence Minerals #KDNC, Open Orphan #ORPH, Bidstack #BIDS and Kibo Energy #KIBO on the Vox Markets podcast
- Open Orphan #ORPH CEO Cathal Friel & Cadence Minerals #KDNC CEO Kiran Morzaria discuss developments on Vox Markets podcast
- Open Orphan #ORPH – Recommended All-Equity Offer for hVIVO #HVO
- Alan Green CEO of Brand Communications talks about: i3 Energy #I3E Cranswick #CWK Tertiary Minerals #TYM Open Orphan #ORPH
- Alan Green discusses Polarean Imaging #POLX, Open Orphan #ORPH & Metro Bank #MTRO on Vox Markets podcast
- Open Orphan’s (ORPH) Maurice Treacy Hosts Value the Markets Webinar
- Open Orphan plc (ORPH) Investor Event Attendance and Presentation
- VIDEO: Open Orphan (ORPH) CCO Maurice Treacy Presents at Shares Investors Evening in Manchester
- Maurice Treacy of Open Orphan #ORPH, plus Alan Green talks Fair Oaks Income #FAIR, Open Orphan #ORPH, Helios Underwriting #HUW & Kibo Energy #KIBO
- Open Orphan #ORPH signs strategic collaboration agreement with Empiric Logic
- Open Orphan #ORPH presents at Shares Investor Evening, Manchester
- Open Orphan (ORPH) – CRUX Asset Management Ltd increase Holding(s) in Company
- Alan Green CEO of Brand Communications talks about: Thomas Cook CVS Group #CVS Open Orphan #ORPH Bidstack #BIDS IMC Exploration #IMCP
- Vox Markets podcast – Open Orphan (ORPH) CEO Cathal Friel explains how they are targeting profitable growth and a return to profitability in 2020.
- Open Orphan #ORPH – Interim Results for 6 months ended 30 June 2019
- Open Orphan (ORPH) Co-Founder and CCO talks about his background, provides an overview of the company and its potential on the Vox Markets Podcast
- Open Orphan #ORPH presents at Total Market Solutions & Proactive Investors’ One2One Forum, London
- Open Orphan (ORPH) CEO Cathal Friel Presentation at Shares London
- Open Orphan (ORPH) CEO Cathal Friel tells Alan Green why he expects 40 percent growth year on year
- Open Orphan (ORPH) Upcoming Investor Events
- Open Orphan (ORPH) CEO Cathal Friel joins Vox Markets for a Q&A session
- Open Orphan Plc (ORPH) Directorate Changes
- Alan Green covers Thomas Cook #TCG, Volga Gas #VGAS, Feedback #FDBK, Open Orphan #ORPH and European Metal Holdings #EMH on Vox Markets podcast
- Open Orphan PLC (ORPH) Exercise of Warrants and Issue of Shares
- Open Orphan (ORPH) Chief Executive Officer, Cathal Friel discuss an operational update on the Vox Markets Podcast with Justin Waite
- Open Orphan (ORPH) sells its remaining shareholding in Integumen plc
- Brand CEO Alan Green talks Open Orphan #ORPH, Volga Gas #VOLG, Thomas Cook #TCG & IMC Exploration #IMC on Vox Markets podcast